ADDA 5 hydrochloride is a partial non-competitive inhibitor of cytochrome c oxidase (CcO) , with IC 50 s of 18.93 μM and 31.82 μM for purified CcO from human glioma and bovine heart, respectively.In VitroADDA 5 hydrochloride is a partial non-competitive inhibitor of CcO, with IC 50 s of 18.93 μM and 31.82 μM for purified CcO from human glioma and bovine heart, respectively. ADDA 5 inhibits CcO activity in UTMZ and Jx22-derived GSCs, with IC 50 s of 21.4 ± 3.9 μM and 15.5 ± 2.8 μM. ADDA 5 (25 μM) shows a growth inhibitory effect on UTMZ cells, with an EC 50 of 8.17 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoADDA 5 (8 mg/kg, i.p.) significantly suppresses the growth of tumor in mice. ADDA 5 does not causes detectable toxicity at up to 80 mg/kg in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:IC50: 18.93 μM (CcO, human glioma), 31.82 μM (CcO, bovine heart). Specification: 0.98 Molecular Formula: C24H36ClNO2 Molecular Weight: 406 PubChem CID: 2882960 Isomeric SMILES: C1CN(CC2=CC=CC=C21)CC(COCCC34CC5CC(C3)CC(C5)C4)O.Cl
- UPC:
- 51131743
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- A647854-5mg
- CAS:
- 473268-46-1
- Product Size:
- 5mg
