AGN 194078 is a selective RARα agonist with a K d and EC 50 of 3 and 112 nM, respectively.In VitroAGN 194078 is a selective RARα agonist and binds to RARα with very high affinity, having a K d value of 3 nM, while being unable to bind to RARβ and binding only very weakly (K d =5600 nM) to RARγ. Furthermore, AGN 194078 maintains full transcriptional activity through RARα, with an EC 50 value of 112 nM, but only activated/nRARβ and RARγ with about 10% efficacy at the highest dose (1000 nM) tested. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:Kd: 4 nM (RARα), EC50: 140 nM (RARα). Specification: 0.98 Molecular Formula: C22H23F2NO4 Molecular Weight: 403.42
- UPC:
- 12352005
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- A647818-10mg
- CAS:
- 321995-62-4
- Product Size:
- 10mg
