Thromboxane (TXA|2|) activates the T prostanoid (TP) receptor. Prostaglandin E|2|(PGE|2|) activates four E prostanoid (EP) receptors, EP|1-4|. AH-23848 is a dual antagonist of TP1 and EP|4|receptors. It originally was found to inhibit TXA2-induced platelet aggregation (IC|50|= 0.26 μM) and the contraction of human bronchial smooth muscle induced by the TP agonist U-46619. AH-23848 was subsequently demonstrated to impair PGE|2|-mediated relaxation of piglet saphenous vein by antagonizing the PGE|2|receptor EP|4|. Through inhibiting EP|4|, it likewise suppresses serum-induced cAMP generation, cyclin A synthesis, as well as the proliferation of fibroblasts, as well as reduces metastasis in a murine model of metastatic breast cancer. Molecular Formula: C29H35NO5 Molecular Weight: 477.6 PubChem CID: 5310999 Isomeric SMILES: C1COCCN1[C@@H]2[C@H]([C@H](CC2=O)OCC3=CC=C(C=C3)C4=CC=CC=C4)CC/C=C/CCC(=O)O Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/A338132-SCI_3c3d384fe43b4b14768bc3f7c801fa01.pdf
- UPC:
- 12141503
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 0.96 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- A338132-1mg
- CAS:
- 81496-19-7
- Product Size:
- 1mg
- Precautionary Statement Codes:
- P264
