Aladdin-1

ML355 ML355 is a potent and selective inhibitor of human 12-Lipoxygenase with an IC50 of 290 nM and shows excellent selectivity over related lipoxygenases and cyclooxygenases.Targets12-LOXIn vitroML355 displays nM potency against 12-LOX and...

ML162 ML162 is a covalent inhibitor of cellular phospholipid glutathione peroxidase (GPX-4) that induces ferroptosis .TargetsGPX-4 Ferroptosis Inhibitors

ML-SI3

ML-9 (Free Base) is a selective and potent inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK) and stromal interaction molecule 1 (STIM1) activity. ML-9 (Free Base) inhibits inhibits MLCK, PKA and PKC activity with Ki values of 4,...

Selective 12/15 LOX inhibitor; activein vivo

Selective negative allosteric modulator of mGlu3receptors

Inhibitor of Clk and DYRK kinases

ML179 (SR-1309) is a inverse LRH1 (Liver receptor homologue-1) agonist with IC50 of 320 nM. ML179 shows anti-proliferation activity in MDA-MB-231 cells.

Novel IKK2-selective inhibitor

MK-8353 (SCH900353) MK-8353 (SCH900353) is an orally bioavailable, selective, and potent ERK inhibitor that inhibits activated ERK1 and ERK2 in vitro, with IC50 values of 23.0 nM and 8.

MK-2894

MK-0941 is a potent, orally active and allosteric glucokinase activator, with EC 50 s of 240 and 65 nM for recombinant human glucokinase in the presence of 2.5 and 10 mM glucose, respectively.