Aladdin™ BS(PEG)5 (C09-1510-594)

Product introduction:BS(PEG)5 is a bis-succinimide ester-activated PEG compound used for crosslinking between primary amines (—NH2) in proteins and other molecules. The :N:-hydroxysuccinimide ester (NHS) groups at either end of the PEG5 spacer react specifically and efficiently with lysine and N-terminal amino groups at pH 7-9 to form stable amide bonds.No-Weigh products are specialty reagents provided in a pre-aliquoted format. The pre-weighed packaging prevents the loss of reagent reactivity and contamination over time by eliminating the repetitive opening and closing of the vial. The format enables use of a fresh vial of reagent each time, eliminating the hassle of weighing small amounts of reagents and reducing concerns over reagent stability.Features of BS(PEG)5:• :Reactive groups:sulfo-NHS ester (both ends):• :Reactive towards: amino groups (primary amines):• NHS esters react with—NH2 groups at pH 7-9, forming stable amide bonds:• Water-soluble; compare to non-pegylatedBS3 (also soluble) andDSS (water-insoluble):• Membrane-impermeable, allowing for cell surface labeling:• Irreversibly crosslink proteins or peptides by flexible PEG spacer arms:• Polyethylene glycol spacer arms help maintain conjugate solubility:• Pure compound with defined structure and molecular weight, ensuring reproducible protein-modification effects:• PEG spacer provides unique advantages, including increased stability, reduced tendency toward aggregation and reduced immunogenicity:• Ideal for small molecule or peptide conjugations:Alternative Names for BS(PEG)n:• Bis-NHS-dPEG:• NHS-PEG-NHS:• BS(PEO)5:• Bis(NHS)PEO5:• BS-PEO9:• dPEG NHS ester:• Bis-succinimide ester PEG 400:Product References:Crosslinker Application Guide -- search for recent literature references for this product:• :Reactive Moiety:Sulfo-NHS Ester :• :Crosslinker Type:Homobifunctional :• :Form:Powder :• :Spacer:Medium(10 to 30 Å) :• :Labeling Method:Chemical Labeling :• :Spacer Arm Length:21.7 Å. Molecular Weight: 532.5