ALB-127158(a) (C09-1102-133)

ALB-127158(a) is a potent and selective melanin concentrating hormone 1 ( MCH 1 ) receptor antagonist.In VitroALB-127158(a) has high affinity for the MCH 1 receptor (7 nM) with good selectivity over a range of other G-protein coupled receptors (GPCRs), ion channels and transporters, including the MCH 2 receptor. In vitro functional assays confirmed that ALB-127158(a) is a potent and selective MCH 1 receptor antagonist. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoIn a mouse diet induced obesity (DIO) model, ALB-127158(a) produces a significant sustained decrease in body weight and food intake in the range of 5-15 mg/kg bid. The weight reduction is predominantly due to a decrease in fat content. In high fat diet (HFD) rats, ALB-127158(a) produces significant weight loss and food reduction at doses as low as 1.25 mg/kg po. Doses > 1.25 mg/kg po produces weight loss > 6%, maximal weight loss of about 10% in rats is observed at 10 mg/kg. Following single and multiple oral administration of ALB-127158(a), ALB-127158(a) is rapidly absorbed (median t max attains between 1 and 3 h post dose in lean and overweight/obese subjects) with a trend to decrease over dose suggesting a slower absorption rate of ALB-127158(a) at lower doses. After single doses, ALB-127158(a) has a mean half-life (t 1/2 ) of 18 to 21 h. Slightly longer mean t 1/2 estimates of approximately 26 h are obtained following multiple dosing in overweight/obese subjects; steady-state plasma ALB-127158(a) is attained within 6 to 8 days of dosing . MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:MCH 1 receptor. Specifications and Purity: 99%. Molecular Formula: C23H21FN4O2. Molecular Weight: 404.44. PubChem CID: 44193892. Isomeric SMILES: CN1C2=C(CNCC2)C3=C1C=C(C=C3)N4C=CC(=CC4=O)OCC5=NC=C(C=C5)F.