General description
A cell-permeable benzamide compound that selectively enhances the activity of both the wild-type ALDH2*1 and the east asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (2.1-, 2.2, and 11-fold activation of 20 µg wt homo, wt/mut hetero, and mut homo tetramer, respectively, at 100 µM), while exhibiting no effect toward alcohol dehydrogenase 1, cytosolic ALDH1, or mitochondrial ALDH5. Both PKCε activatior- and ethanol-mediated protections against heart tissue ischemic damage are reported to correlate well with ALDH2 activation, and Alda-1, likewise, is shown to protect against ischemic tissue damage to excised rat hearts (26% and 24% reduction in infarct size and CPK release, respectively; 20 µM) ex vivo and anesthetized live rats (60% infarction reduction; 8.5 mg/kg) in vivo.
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following, reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Chen, C.H., et al. 2008. Science321, 1493.
Legal Information
Patent pending.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
- UPC:
- 51143020
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 126920-25MG
