Allo-aca (C09-1103-231)

Allo-aca, a leptin peptidomimetic, is a potent, specific leptin receptor antagonist peptide. Allo-aca blocks leptin signaling and action in numerous in vitro and in vivo models.Appearance:SolidIn Vitro:Allo-aca inhibits leptin-induced proliferation of MDA-MB-231 cells at 50 pM concentration. Allo-aca inhibits leptin-induced proliferation of MCF-7 cells with an IC 50 of 200 pM. Allo-aca at 250 nmol/L reduces VEGF-dependent leptin mRNA expressionIn Vivo:In an MDA-MB-231 orthotopic mouse xenograft model, Allo-aca administered subcutaneously significantly extends the average survival time from 15.4 days (untreated controls) to 24 and 28.1 days at 0.1 and mg/kg/day doses, respectively. MCE has not indBiological Activity:Allo-aca, a leptin peptidomimetic, is a potent, specific leptin receptor antagonist peptide. Allo-aca blocks leptin signaling and action in numerous in vitro and in vivo models . Specifications and Purity: 99%. Molecular Formula: C48H75N13O15. Molecular Weight: 1074.19.