General description
Recombinant, mouse α-interferon expressed in E. coli. Antiviral and anti-neoplastic agent. Suppresses bone marrow function and induces apoptotic cell death in non-melanoma skin cancer. IFN-α signaling is mediated by JAK1 and TYK2 tyrosine kinases. Note: 1 KU = 1000 units.
Recombinant, mouse α-interferon expressed in E. coli. Antiviral, antineoplastic agent. Expressed during the triggering stage of macrophage cytocidal activation. Suppresses bone marrow function and cell proliferation. Modulates the immune response. Also known to induce apoptotic cell death in non-melanoma skin cancer.
Warning
Toxicity: Standard Handling (A)
Unit Definition
One unit of interferon per ml of medium will cause a 50% inhibition of EMCV-induced cytopathic effect on mouse L929 cells. Units are determined with respect to the NIH international reference standard for mouse IFN-α.
Other Notes
Krishnan, K., et al. 1997. Eur. J. Biochem. 247, 298.
Rodriquez-Villanueva, S., and McDonnel, T.J. 1995. Int. J. Cancer61, 110.
Dianzani, F. 1993. Gut34, 574.
Brouty-Boyce, D., and Zetter, B.R. 1990. Science208, 516.
Sidky, Y.A., and Borden, E.C. 1987. Cancer Res.47, 5155.
Daugherty, B.L., and Pestka, S. 1986. Methods Enzymol.119, 34.
Pestka, S. 1986. Methods Enzymol.119, 14.
Familletti, P.C., et al. 1981. Methods Enzymol.78, 387.
Johnson, M.D., et al. 1981. Methods Enzymol.78, 394.
Rubinstein, S., et al. 1981. J. Virol.37, 755.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Assay: ≥. 95% (SDS-PAGE). Quality Level: 100. form: liquid. specific activity: ≥. 3.5 x 104 . units/mL. manufacturer/tradename: Calbiochem®. . storage condition: OK to freeze, avoid repeated freeze/thaw cycles. shipped in: wet ice. storage temp.: −. 70°C. Storage Class Code: 10 - Combustible liquids. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable.- UPC:
- 41116127
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 407293-100KU
