Alsterpaullone, 2-Cyanoethyl is an alsterpaullone derivative that acts as a highly potent, ATP-competitive, selective inhibitor of Cdk1/cyclin B and GSK-3β (IC50 = 230 pM and 800 pM, respectively; [ATP] = 15 μM). Alsterpaullone, 2-Cyanoethyl displays ~37-fold greater selectivity for Cdk1/cyclin B over Cdk5/p25 (IC50 = 30 nM). In a commercially available testing screen panel, Alsterpaullone, 2-Cyanoethyl was shown to inhibit other kinases (pIC50 = -logIC50[M]; pIC50 ~ 7.5, 7.0, 7.0, 6.5, 6.5, 6.0, and 6.0 for Cdk2/A, Cdk4/D1, GSK-3β, PDGFRβ, Src, VEGFR-2, and VEGFR-3, respectively; [ATP] = 1 μM). Specification: ≥97% Molecular Formula: C19H14N4O3 Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/A336672-SCI_b762747dbbebc51221bc2e03ccde0631.pdf
- UPC:
- 12352117
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 0.96 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- A336672-1mg
- CAS:
- 852529-97-0
- Product Size:
- 1mg
- Precautionary Statement Codes:
- P264
