Ammonium acetate (C15-1254-682)

General description

Ammonium acetate (NH₄CH₃CO₂, NH₄OAc) is a water-soluble, hygroscopic ammonium salt. It is an eco-friendly and inexpensive compound that can be prepared by reacting glacial acetic acid with ammonia or ammonium carbonate. It is used as a catalyst as well as a source of ammonia in organic synthesis.

Application

Ammonium acetate can be used as a reactant as well as a catalyst in the synthesis of:      

• 1,3-oxazine derivatives by three-component condensation reaction with 2-naphthol and aromatic aldehydes.      
• Symmetrical terpyridine derivatives by treating with aromatic aldehydes and ethyl cyanoacetate.      
• Isoquinolines, furopyridines, and thienopyridines via Pd-catalyzed sequential coupling-imination-annulation reactions of ortho-bromoarylaldehydes and terminal alkynes.

It can also be used as a nitrogen source to synthesize benzoxazole derivatives via multicomponent condensation reaction with catechols, and various aldehydes in the presence of Fe(III)−salen complex as a catalyst.

Features and Benefits

NH₄OAc is an eco-friendly, shelf-stable, and safe reagent.