General description
A cell-permeable furancarboxylic acid compound that activates celular AMP-activated protein kinase (AMPK) activity by inhibiting mitochondrial complex I, and thus elevating intracellular AMP level. Shown to enhance glucose uptake in L6 myocytes (EC50 = 11.7 µM). Reduces blood glucose levels in ZDF rats in vivo (oral dose 30-100 mg/kg). Displays negligible cytotoxicity at pharmacological doses.
Biochem/physiol Actions
Cell permeable: yes
EC50 = 11.7 µM enhancing glucose uptake in L6 myocytes
Primary Target
AMPK
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Warning
Toxicity: Irritant (B)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Kosaka, T., et al. 2005. Anal. Chem.77, 2050.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
- UPC:
- 41141613
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 171256-5MG