Biochem/physiol Actions
AMPK is a heterotrimer protein kinase consisting of a α catalytic subunit, and non-catalytic β and γ subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated and phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating biosynthesis of fatty acid and cholesterol.
Physical form
Supplied in 50mM NaPhosphate pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1mM PMSF, 0.2 mM DTT, 25% glycerol.
Legal Information
PRECISIO is a registered trademark of Sigma-Aldrich Co. LLC
recombinant: expressed in baculovirus infected Sf9 cells. Quality Level: 200. product line: PRECISIO®. Kinase. Assay: ≥. 70% (SDS-PAGE). form: buffered aqueous glycerol solution. specific activity: 626-848 . nmol/min·mg. mol wt: A1 subunit ~68 . kDa, B1 subunit ~38 . kDa, G1 subunit ~40 . kDa. UniProt accession no.: P54619, Q13131, Q9Y478. shipped in: dry ice. storage temp.: −. 70°C. Gene Information: human ... PRKAA1(5562), PRKAB1(5564), PRKAG1(5571). Pictograms: GHS07,GHS08. Signal Word: Danger. Hazard Statements: H315 - H319 - H360D. Precautionary Statements: P202 - P264 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313. Hazard Classifications: Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2. Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter.- UPC:
- 41181903
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- A1233-10UG
