Biochem/physiol Actions
AMPK (A1/B1/G3) is a member of the AMPK family which are heterotrimeric proteins consisting of an α catalytic subunit, and non-catalytic β and γ subunits. AMPKs are an important energy-sensing enzyme group in the cells that monitor energy status particularly in response to stress. AMPKs regulate fatty acid and cholesterol synthesis by regulating the key rate-limiting enzymes acetyl-CoA carboxylase and 3-hydroxy-3-methylglutaryl-CoA reductase. The γ subunit is dominantly expressed in skeletal muscle where it may play a key role in the regulation of energy metabolism.
Physical form
Supplied in 50 mM Sodium Phosphate, pH 7.0, with 150 mM imidazole, 0.1 mM PMSF, 0.2 mM DTT, and 25% glycerol.
Legal Information
PRECISIO is a registered trademark of Sigma-Aldrich Co. LLC
recombinant: expressed in baculovirus infected Sf9 cells. Quality Level: 200. product line: PRECISIO®. Kinase. Assay: ≥. 70% (SDS-PAGE). form: buffered aqueous glycerol solution. specific activity: 157-213 . nmol/min·mg. mol wt: A1 subunit ~68 . kDa, B1 subunit ~38 . kDa, G3 subunit ~51 . kDa. UniProt accession no.: Q13131, Q9UGI9, Q9Y478. shipped in: dry ice. storage temp.: −. 70°C. Gene Information: human ... PRKAA1(5562), PRKAB1(5564), PRKAG3(53632). Pictograms: GHS08. Signal Word: Danger. Hazard Statements: H360D. Precautionary Statements: P201 - P202 - P280 - P308 + P313 - P405 - P501. Hazard Classifications: Repr. 1B. Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable.- UPC:
- 41116133
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- A4486-10UG
