General description
A potent inhibitor of the amyloid precursor protein (APP) β-secretase (IC50 = 30 nM).
Biochem/physiol Actions
Cell permeable: no
Primary Target
APP
Product does not compete with ATP.
Reversible: no
Target IC50: 30 nM against amyloid precursor protein (APP) β-secretase
Warning
Toxicity: Standard Handling (A)
Sequence
H-Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Stat-Val-Ala-Glu-Phe-OH [Stat = (3S,4S)-Statine]
Physical form
Supplied as a trifluoroacetate salt.
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Sinha, S., et al. 1999. Nature 402, 537.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
- UPC:
- 51172437
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 171601-500UG