β-Amyrone (C09-1102-957)

β-Amyrone (β-Amyron) is a triterpene compound which has anti-inflammatory activity through inhibiting the expression of COX-2 . β-Amyrone has antifungal activity , as well as antiviral activity against Chikungunya virus. β-Amyrone also inhibits α-glucosidase and acetylcholinesterase ( AChE ) activity. β-Amyrone can be used in the research of disease like inflammation, infection , and obesityIn Vitroβ-Amyrone (1.25-10 μg/mL, 24 h) inhibits on NO ∙ production in LPS-stimulated J774 cells, with an IC 50 value of 4.61 μg/mL, and has no obvious effect on cell viability. β-Amyrone (10 μg/mL, 24 h) inhibits IL-6, IL-10 levels, and COX-2 expression in LPS-stimulated J774 cells. β-Amyrone (0-235 μM, 7days) has antiviral activity in Vero cells against Chikungunya virus (CHIKV), with EC 50 value of 86 uM. β-Amyrone inhibits α-glucosidase, acetylcholinesterase (AChE) and fungal activity with IC 50 values of 25 μM, 23 μM and 8 μg/mL, respectively . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: LPS (1 μg/mL)-stimulated J774 cells Concentration: 2.5, 5, 10 μg/mL Incubation Time: 24 h Result: Inhibited COX-2 expression in a concentration-dependent manner (approximately 90% reduction at 5 or 10 μg/ mL).In Vivoβ-Amyrone (local administration on ear, 0.1-0.6 mg/kg, a single dose) inhibits ear edema formation in phenol-induced edema mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Ear phenol-induced edema in Balb C mice Dosage: 0.1, 0.3, 0.6 mg/kg, a single dose Administration: Local administration (20 ?L solution) on ear Result: Inhibited ear edema formation in a dose-related manner (47% inhibition at the dose of 0.6mg/kg).IC50& Target:COX-2. Specification: 0.99 Molecular Formula: C30H48O Molecular Weight: 424.7 PubChem CID: 6454747 Isomeric SMILES: C[C@@]12CC[C@@]3(C(=CC[C@H]4[C@]3(CCC5[C@@]4(CCC(=O)C5(C)C)C)C)[C@H]1CC(CC2)(C)C)C