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ANAGRELIDE HYDROCHLORIDE (C005B-312869)

Catalog No.
C005B-312869
Mfr. No.
SML0846-50MG
Mfr. Name
Sigma-Aldrich
Qty/UOM
50
UOM
MG
Price: $918.71
List Price: $1,020.79

General description Download the CofA, SDS and IFU specific to your product lot and format Fab fragments from polyclonal anti-fluorescein antibodies, conjugated to alkaline phosphatase. After immunization with fluorescein, the sheep IgG was

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General description

Download the CofA, SDS and IFU specific to your product lot and format
Fab fragments from polyclonal anti-fluorescein antibodies, conjugated to alkaline phosphatase.
After immunization with fluorescein, the sheep IgG was purified by ion exchange chromatography and the specific IgG was isolated by immunosorption. The Fab fragments obtained by papain digestion were purified by gel filtration, conjugated with alkaline phosphatase, and stabilized in 50 mM triethanolamine buffer, 3 M NaCl, 1 mM MgCl2, 0.1 mM ZnCl2, 1% bovine serum albumin (w/v), pH 7.6.
Clone: polyclonal
Ig class: sheep IgG, Fab fragments

Anagrelide belongs to the imidazo[2,1-b]quinazolin-2-one series of compounds.

Biochem/physiol Actions

Anagrelide is a phosphodiesterase inhibitor with antiplatelet activity (IC50 = 36 nM for inhibition of phosphodiesterase-III). Anagrelide inhibits the maturation of megakaryocytes into platelets, reducing both megakaryocyte hyperproliferation and differentiation. As a drug, anagrelide is antithrombocythemic used for the treatment of overproduction of blood platelets.

Anagrelide is a phosphodiesterase inhibitor with antiplatelet activity.

In human and animals, anagrelide has an inhibitory effect on platelet aggregation. Small doses of anagrelide can generate thrombocytopenia. Anagrelide is not advised during pregnancy. It is effectively used in the treatment of essential thrombocytosis.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

UPC:
51101663
Condition:
New
Availability:
3-5 Days
Weight:
1.00 Ounces
HazmatClass:
No
MPN:
SML0846-50MG
CAS:
58579-51-4

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