ANAPHASE-PROMOTING COMPLEX I 1PC X 50MG (C005B-022498)

Catalog No.: C005B-022498
Mfr. No.: 172104-50MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 50
UOM: MG

Price: $205.58

List Price: $228.42

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Description
Specifications

General description

TAME is a potent ubiquitin ligase inhibitor that specifically blocks Anaphase-Promoting Complex (APC) activation by directly binding to APC and disrupts the IR-tail-dependent interactions between APC and its activator proteins Cdc20 or Cdh1. It stabilizes APC substrates and is shown to inhibit cyclin proteolysis in mitotic Xenopus egg extract with an IC₅₀ = 12 µM.

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Sackton, K.L., et al. 2014. Nature. In press.
Zeng, X., et al. 2010. Cancer Cell18, 382.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

UPC:: 41116012
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: No
MPN:: 172104-50MG
CAS:: 1784-03-8

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