Angiotensin II 5-valine is an agonist of angiotensin receptor .In VivoBy day 12, systolic blood pressure (SBP) increases significantly in Angiotensin II 5-valine infused rats (197±7 mm Hg).The development of hypertension in ANG II infused rats is prevented by losartan treatment. Blood and kidney samples are harvested, subjected to HPLC to separate Angiotensin II 5-valine (exogenous) from Ile5-ANG II (endogenous) and the fractions are measured by radioimmunoassay. In the Angiotensin II 5-valine infused rats treated with losartan, total plasma ANG II levels are elevated to a greater extent than in rats not treated with losartan (289±20 v 119±14 fmol/mL). However, losartan markedly decrease by 88% the enhancement of intrarenal Val5-ANG II content that occurred in the rats infused with Val5-ANG II alone . MCE has not independently confirmed the accuracy of these methods. They are for reference only.IC50& Target:Angiotensin receptor. Specification: 10mM in Water Molecular Formula: C49H69N13O12 Molecular Weight: 1032.2
- UPC:
- 51432313
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- A655627-1ml
- CAS:
- 58-49-1
- Product Size:
- 1ml
