ANLE138B (C005B-312001)

Catalog No.: C005B-312001
Mfr. No.: SML1515-5MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 5
UOM: MG

Price: $260.50

List Price: $289.44

Biochem/physiol Actions Anle138b is a fluorescent inhibitor of α:-synuclein and prion-protein (PrPSc) aggregation that reduces the progression of prion and Parkinson′:s disease in animal models. Anle138b extends the survival of mice

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Biochem/physiol Actions

Anle138b is a fluorescent inhibitor of α-synuclein and prion-protein (PrPSc) aggregation that reduces the progression of prion and Parkinson′s disease in animal models. Anle138b extends the survival of mice infected with prions. Anle138b strongly inhibits BSE-derived and human prions. The fluorescence strongly increases upon binding with α-synuclein fibrils. Apparently, Anie138b binds to hydrophobic pockets in the fibrils.

Anle138b, an oligomer modulator, inhibits neuronal degeneration. It rescues neurons from the aggregation effects of α-synuclein.

UPC:: 12352200
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: No
MPN:: SML1515-5MG
CAS:: 882697-00-9

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