General description
Mammals express seven distinct 14-3-3 isoforms (gamma, epsilon, beta, zeta, sigma, theta, tau) that form multiple homo- and hetero- dimmers, thus rendering 14-3-3 as a key multifunctional regulatory molecule. 14-3-3 isomers have been implicated in several neurological disorders: for example isoforms gamma, epsilon and beta are expressed in the cerebrospinal fluid of Creutzfeldt-Jakob patients, but not patients suffering from other neurological conditions such as Alzheimer′s.
The 14-3-3 sigma antibody is one of a panel of antibodies that were generated against 14-3-3 isoforms and have demonstrated their potential for use as an ELISA-based diagnostic tool. These antibodies will allow the research to investigate the role of this protein in key cellular processes and neurological disorders such as Creutzfeldt-Jakob, Alzheimer′s and Parkinson′s Disease.
Specificity
14-3-3 sigma. By Western blot the antibody recognizes the ~30 kDa protein.
Immunogen
Synthetic peptide from the N-terminal area of sheep 14-3-3 sigma.
Application
Anti-14-3-3 σ Antibody is an antibody against 14-3-3 σ for use in WB.
Research Category
Neuroscience
Research Sub Category
Neurodegenerative Diseases
Western blot: 1:3000
Optimal working dilutions must be determined by end user.
Physical form
Liquid.
Serum
Storage and Stability
Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
biological source: rabbit. Quality Level: 100. antibody form: serum. antibody product type: primary antibodies. clone: polyclonal. species reactivity: chicken, bovine, rat, human, sheep, mouse. manufacturer/tradename: Chemicon®. . technique(s): western blot: suitable. NCBI accession no.: NM_006142.3. UniProt accession no.: P31947. shipped in: dry ice. target post-translational modification: unmodified. Gene Information: bovine ... Sfn(528453)chicken ... Sfn(408037)
human ... SFN(2810)
mouse ... Sfn(55948)
rat ... Sfn(313017)
sheep ... Sfn(443032). Storage Class Code: 11 - Combustible Solids. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable.
Shipping Information:
Dry Ice Surcharge & Ice Pack Shipments: $40
More Information: https://cenmed.com/shipping-returns
- UPC:
- 41116012
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- AB9742
- Temperature Control Device:
- Yes
