ANTI-ACTIVIN A DEVELOPED IN GOAT AFFINITY ISOLATED ANTIBODY (C005B-238766)

General description

Activin A protein belongs to the transforming growth factor-β (TGF-β) superfamily. This protein is a homodimer of two βA subunits. The INHBA gene is located on the human chromosome at 7p14.1.

Immunogen

recombinant human activin A expressed in CHO cells.

Application

Anti-Activin A antibody can be used for immunohistochemistry (5-15 μg/mL), western blot (0.1 μg/mL) and neutralization assays.

Anti-Activin A antibody produced in goat has been used in immunohistochemical staining.

Biochem/physiol Actions

Activin A protein is involved in regulating developmental genes such as cell cycle regulators like p21, p15, paired box protein (Pax-6) and hormones like follicle-stimulating hormone (FSH). This protein also regulates its antagonist like follistatin and mothers against decapentaplegic homolog 7 (SMAD7). Activin A protein binds to the type 1 receptor activin receptor type 1B (ActR1B) and type 2 receptor activin receptor 2A and 2B (ActRIIA and ActRIIB). Activin A gene is highly expressed in esophageal carcinoma, lung adenocarcinoma, and malignant pleural mesothelioma (MPM). This gene expression is decreased during breast cancer, neuroblastoma, and hepatocellular carcinoma (HCC). Activins bind to the type II Activin receptor triggering phosphorylation of type I Activin receptor (ALK4) and activation of downstream pathways such as proliferation and apoptosis. Activin acts as a tumor suppressor by reducing cell proliferation in cancer cells.

Physical form

Lyophilized from 0.2 μm-filtered solution in phosphate buffered saline containing carbohydrates.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

biological source: goat. Quality Level: 100. recombinant: expressed in goat. conjugate: unconjugated. antibody form: affinity isolated antibody. antibody product type: primary antibodies. clone: polyclonal. form: lyophilized powder. species reactivity: human. technique(s): ELISA: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): 5-15 . μ. g/mL, neutralization: suitable, western blot: 0.1 . μ. g/mL. UniProt accession no.: P08476. application(s): research pathology. storage temp.: −. 20°C. target post-translational modification: unmodified. Gene Information: human ... INHBA(3624). Storage Class Code: 11 - Combustible Solids. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable.