Anti-ALDOC antibody produced in rabbit (C15-1445-877)

General description

ALDOC (Fructose-bisphosphate aldolase C) gene encodes a glycolytic enzyme belonging to the fructose-biphosphate aldolase gene family. Aldolase isozymes A, B and C form the class I enzymes found in mammals. The isozyme aldolase C is mainly expressed in brain and neuronal tissue. These isozymes have conserved residues in the catalytic site forming the Schiff-base intermediate. Isozyme C is found to be expressed in proliferating and cancer cells.

Immunogen

Fructose-bisphosphate aldolase C recombinant protein epitope signature tag (PrEST)

Application

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

Biochem/physiol Actions

Fructose-bisphosphate aldolases catalyze the reversible aldol cleavage of fructose-1,6-(bis)phosphate to dihydroxyacetone phosphate (DHAP) and fructose 1-phosphate to either glyceral-dehyde-3-phosphate (G3P) or glyceraldehyde. Aldolase C has been implicated in cell growth, vertebrate development, and other metabolic processes. Its expression is upregulated by nerve-growth-factor-induced B factor, a transcription factor of the thyroid/steroid/retinoid nuclear receptor gene family, suggesting that this isozyme may also have a neurodevelopmental role.

Features and Benefits

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Linkage

Corresponding Antigen APREST86404.

Physical form

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Legal Information

Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.