ANTI-ANGIOMOTIN (RABBIT POLYCLONAL) (C15-1317-680)

General description

Angiomotin is a cell surface protein that plays a central role in tight junction maintenance and the uptake of proteins at tight junctions but also appears to regulate endothelial cell response and their migration toward growth factors as well as their response to angiostatin. Thus Angiomotin plays a role in blood vessel formation, cell migration, protein localization, chemotaxis, cellular polarity and many more cell-movement/migration activities. Angiomotin is a component of a multi-protein complex associated at tight junctions that includes ARHGAP17, AMOT, MPP5/PALS1, INADL/PATJ and PARD3/PAR3 proteins. Angiomotin is expressed in endothelial cells and found in placenta, blood vessels and skeletal muscle tissue, as well as at the leading edge of lamellipodia and cellular processes.

Specificity

This antibody detects p80 and p130 forms of AMOT

Immunogen

Linear peptide corresponding to human Angiomotin.

Application

Anti-Angiomotin Antibody | ABS1023 is an antibody against Angiomotin Antibody for use in Western Blotting, Immunoprecipitation, Immunofluorescence, Immunocytochemistry, Chromatin Immunoprecipitation (ChIP).

Research Category
Signaling

Research Sub Category
Signaling Neuroscience

Quality

Evaluated by Western Blotting in HEK293 transfected with LATS cell lysate.

Western Blotting Analysis: A 1:5,000 dilution of this antibody detected Angiomotin in 10 µg of HEK293 transfected with LATS cell lysate.

Target description

150/80 kDa observed

Physical form

Affinity purified

Purified rabbit polyclonal in buffer containing PBS with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Other Notes

Concentration: Please refer to lot specific datasheet.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

biological source: rabbit. Quality Level: 100. antibody form: affinity isolated antibody. antibody product type: primary antibodies. clone: polyclonal. purified by: affinity chromatography. species reactivity: human. species reactivity (predicted by homology): bovine (based on 100% sequence homology). technique(s): ChIP: suitable, immunocytochemistry: suitable, immunofluorescence: suitable, immunoprecipitation (IP): suitable, western blot: suitable. NCBI accession no.: NP_001106962. UniProt accession no.: Q4VCS5. shipped in: wet ice. target post-translational modification: unmodified. Gene Information: human ... AMOT(154796). Storage Class Code: 10 - Combustible liquids. WGK: WGK 2.

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