Anti-ARMS2 Antibody (C15-1317-389)

General description

Age-related maculopathy susceptibility protein 2 (ARMS2) is highly expressed in the human placenta and retina. The biological function of ARMS2 has not been fully characterized. However, previous studies have linked mutations in the ARMS2 and HtrA1 genes, located on chromosome 10q26, to the occurrence of age-related macular degeneration type 8, a condition of irreversible vision loss in the elderly.

Immunogen

KLH-conjugated linear peptide corresponding to human ARMS2.

Application

Immunocytochemistry Analysis: A representative lot was used by an independent laboratory in ARPE-19 cells. (Pericak-Vance, M., et al. (2009). Invest Ophthalmol Vis Sci. 50(7): 3084–3090.)

Research Category
Neuroscience

Research Sub Category
Neurodegenerative Diseases

This Anti-ARMS2 Antibody is validated for use in Western Blotting for the detection of ARMS2.

Quality

Evaluated by Western Blot in human placenta tissue lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected ARMS2 on 10 µg of human placenta tissue lysate.

Target description

~12 kDa observed. An uncharacterized band appears at ~60 kDa in some lysates.

Physical form

Affinity purified

Purified rabbit polyclonal in PBS containing 0.1% azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
Human placenta tissue lysate

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

biological source: rabbit. Quality Level: 100. antibody form: affinity isolated antibody. antibody product type: primary antibodies. clone: polyclonal. purified by: affinity chromatography. species reactivity: human. technique(s): western blot: suitable. NCBI accession no.: NP_001093137. UniProt accession no.: P0C7Q2. shipped in: wet ice. target post-translational modification: unmodified. Gene Information: human ... ARMS2(387715). Storage Class Code: 10 - Combustible liquids.