General description
AS160 (Akt substrate of 160 kDa, also known as TBC1 domain family member 4 (TBC1D4)) gene is mapped to human chromosome 13q22.2 and encodes a Rab guanosine triphosphatase (GTPase)-activating proteins (RabGAP) protein. AS160 is expressed in many differentiated tissues such as adipocytes and skeletal muscles.
Application
Anti-AS160 antibody produced in rabbit has been used in immunoblotting and immunofluorescence.
Biochem/physiol Actions
AS160 is known to play an inhibitory role in the transport of glucose transporter 4 (GLUT4) vesicles. It is associated with GLUT4 vesicles in basal states and dissociates in response to insulin. Reduced expression of AS160 in adipocytes has been shown to increase plasma membrane levels of GLUT4 in an insulin-dependent manner.
Physical form
Solution in 0.01 M phosÂÂphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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- UPC:
- 12352202
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- SAB4200101-200UL
- Temperature Control Device:
- Yes
