General description

ATP13A2 is a member of the P5 family of ATPases which function in the transport of inorganic cations.

ATPase type 13 A2 (ATP13A2), also known as Parkinson′s disease 9 (PARK9), codes for P-type ATPase that is present on the lysosomal membrane with ten transmembrane domains.

Application

Anti-ATP13A2 (C-terminal) antibody produced in rabbit has also been used in immunohistochemistry.

Rabbit Anti-ATP13A2 (C-terminal) antibody has be used for immunofluorescence and western blotting assays.

Biochem/physiol Actions

ATPase type 13A2 (ATP13A2) plays a vital role in regulation of mitochondrial bioenergetics by macroautophagy. Mutations in the ATP13A2 gene leads to the development of hereditary form of Parkinson associated with dementia, known as Kufor-Rakeb syndrome (KRS).

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

biological source: rabbit. Quality Level: 200. conjugate: unconjugated. antibody form: affinity isolated antibody. antibody product type: primary antibodies. clone: polyclonal. form: buffered aqueous solution. mol wt: antigen ~129 . kDa. species reactivity: mouse, human. enhanced validation: recombinant expression
Learn more about Antibody Enhanced Validation. concentration: ~1.5 . mg/mL. technique(s): western blot: 1-2 . μ. g/mL using mouse brain extract (S1 fraction), western blot: 2-4 . μ. g/mL using extract of HEK-293T cells expressing human ATP13A2. UniProt accession no.: Q9NQ11. shipped in: dry ice. storage temp.: −. 20Â°C. target post-translational modification: unmodified. Gene Information: human ... ATP13A2(23400)
mouse ... Atp13a2(74772). Storage Class Code: 10 - Combustible liquids. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US).