ANTI-ATR ANTIBODY (C005B-240584)

General description

The Anthrax toxin receptor 1 (also known as Tumor endothelial marker 8, ANTXR1 and ATR) was initially discovered as the tumor endothelial marker (TEM8). This protein, which exists in three isoforms (33, 37, 41, and 63 kDa), is highly expressed in tumor vessels as well as in the vasculature of developing embryos, suggesting that it may normally play a role in angiogenesis. However, it also acts as the receptor for anthrax toxin. Following the binding of this protein by the protective antigen (PA) of anthrax, PA is cleaved and heptamerizes to form the binding site for both edema factor (EF) and lethal factor (LF). This complex is then endocytosed by the cell; acidification in endosomes allows the release of EF and LF into the cytoplasm where they interfere with MAPK signaling and induce apoptosis.

Immunogen

Epitope: Center region

KLH-conjugated linear peptide corresponding to 13 amino acids near the center region of human ATR.

Application

Anti-ATR Antibody is a highly specific rabbit polyclonal antibody, that targets ATR & has been tested in western blotting, IHC & ICC.

Immunohistochemistry Analysis: 2 μg/mL from a representative lot detected ATR in human brain tissue.

Immunocytochemistry Analysis: 10 μg/mL from a representative lot detected ATR in human brain cells.

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

Quality

Evaluated by Western Blotting in HepG2 cell lysate.

Western Blotting Analysis: 2 μg/mL of this antibody detected ATR in HepG2 cell lysate.

Target description

~41 kDa observed. Uncharacterized bands may be observed in some lysate(s).

Physical form

Purified by Ion-Exchange Chromatography

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

biological source: rabbit. Quality Level: 100. antibody form: purified antibody. antibody product type: primary antibodies. clone: polyclonal. purified by: affinity chromatography. species reactivity: human. technique(s): immunocytochemistry: suitable, immunohistochemistry: suitable, western blot: suitable. UniProt accession no.: Q9H6X2. shipped in: wet ice. target post-translational modification: unmodified. Gene Information: human ... ANTXR1(84168). Storage Class Code: 12 - Non Combustible Liquids. WGK: WGK 2. Flash Point(F): Not applicable. Flash Point(C): Not applicable.

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