ANTI-BAF180 ANTIBODY (C15-1317-219)

General description

BRG1-associated factor 180 (BAF180) is a subunit of the SWI/SNF-B (PBAF) chromatin remodeling complex, and is known to contain 6 bromo domains, 2 BAH domains, and a single HMG box DNA-binding domain. BAF180 has a critical and active role in the transcriptional activation and repression of specific genes via chromatin remodeling, including genes involved in the development of the heart, thus suggesting a role in mammalian development. Recent studies demonstrate BAF180 to suppress tumorigenesis through its ability to regulate both baseline and signal-dependent p21 transcription by its binding of the p21 promoter. Expression of BAF180 is reported in a wide range of tissues.

Immunogen

GST-tagged recombinant protein corresponding to human BAF180.

Application

Anti-BAF180 Antibody is a Rabbit Polyclonal Antibody for detection of BAF180 also known as protein polybromo-1, BRG1-associated factor 180 & has been validated in WB.

Chromatin Immunoprecipitation Analysis: A representative lot was used by an independent laboratory in ChIP (Xia, W., et al. (2008).

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Chromatin Biology

Quality

Evaluated by Western Blot in HEK293 cell lysate.

Western Blot Analysis: A 1:1,000 dilution of this antibody detected BAF180 in 10 µg of HEK293 cell lysate.

Target description

~193 kDa observed

Physical form

Format: Purified

Protein G Purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
HEK293 cell lysate

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

biological source: rabbit. Quality Level: 100. antibody form: purified antibody. antibody product type: primary antibodies. clone: polyclonal. species reactivity: human, mouse, rat. technique(s): ChIP: suitable, western blot: suitable. NCBI accession no.: NP_060635. UniProt accession no.: Q86U86. shipped in: wet ice. target post-translational modification: unmodified. Gene Information: human ... PBRM1(55193). Storage Class Code: 12 - Non Combustible Liquids. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable.

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