General description
Bcl-X consists of two isoforms, Bcl-XL (long), a 241 aa protein, and Bcl-XS (short), a 178 aa protein lacking a 63-aa domain that is well conserved among members of the Bcl-2 family. Bcl-XL represses cell death, while Bcl-XS favors cell death.Bcl-X has two isoforms, Bcl-XL (long) a 241 amino acid protein and Bcl-XS (short) a 178 amino acid protein lacking a 63 amino acid domain that is well conserved among members of the Bcl-2 family. Bcl-XL represses cell death, while Bcl-XS favors cell death.
Specificity
MAB4619 recognizes a protein of 27 kDa, identified as the Bcl-XL protein. Highly specific to Bcl-XL and shows no cross-reaction with Bcl-XS, Bcl-2alpha or Bax protein.
Immunogen
Synthetic peptide corresponding to amino acids 35-50 (TEAPEETEAERETPSA) of mouse Bcl-XL protein. This sequence is conserved at 15 of 16 residues in rat Bcl-XL.
Application
Immunofluorescence
Flow Cytometry
Optimal working dilutions must be determined by end user.
This Anti-Bcl-XL Antibody, N-terminus, clone 7D9 is validated for use in FC, IF for the detection of Bcl-XL.
Physical form
Format: Purified
Immunoglobulin purified by protein A affinity chromatography. Liquid in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Shipping Information:
Dry Ice Surcharge & Ice Pack Shipments: $40
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- UPC:
- 51201651
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- MAB4619
- Temperature Control Device:
- Yes
