General description
Bcl-XL is one of the anti-apoptotic members of the Bcl-2 family of apoptosis regulators and is overexpressed in many human cancers. Studies by Dr. Haldar and his associates suggest that microtubule damaging drugs like Taxol or 2-methoxyestradiol induce phosphorylation of Bcl-XL at serine 62 by kinases such as Jun and this allows those cells to die by apoptosis.
Specificity
AB3116 is specific for the Bcl-xL phosphorylated on serine 62. It does not recognize the unphosphorylated form of the protein.
Immunogen
Epitope: Phospho-specific
Synthetic phosporylated peptide corresponding to a sequence encompassing serine 62 of human Bcl-xL conjugated to KLH.
Application
Detect Bcl-xL using this Anti-Bcl-xL Antibody, Phospho-specific validated for use in WB.
Immunoblotting: Recommended dilution is 1:100
Optimal dilutions must be determined by end-user.
Research Category
Apoptosis & Cancer
Research Sub Category
BCL2 & Inhibition
Tumor Markers
Physical form
Liquid rabbit serum containing no preservatives.
Storage and Stability
Maintain at -80°C for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
biological source: rabbit. Quality Level: 100. antibody form: serum. antibody product type: primary antibodies. clone: polyclonal. species reactivity: human. manufacturer/tradename: Chemicon®. . technique(s): western blot: suitable. NCBI accession no.: NM_001191.2, NM_138578.1. UniProt accession no.: Q07817. shipped in: dry ice. target post-translational modification: unmodified. Gene Information: human ... BCL2L1(598). Storage Class Code: 10 - Combustible liquids. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable.Shipping Information:
Dry Ice Surcharge & Ice Pack Shipments: $40
More Information: https://cenmed.com/shipping-returns
- UPC:
- 51112202
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- AB3116
- Temperature Control Device:
- Yes
