General description
Bcl-2(B-cell lymphoma 2)-like protein 11 (BCL2L11) also known as Bcl-2 interacting mediator of cell death (BIM), belongs to BH3-only death activator family. In human chromosome, the gene BCL2L11 is localized on 2q13.
Immunogen
Peptide sequence around aa. 67-71 (P-A-S-P-G), according to the protein BCL2L11.
Biochem/physiol Actions
Bcl-2-like protein 11 (BCL2L11) is a key factor for determining the cell fate in the absence of cytokines. BCL2L11 is a pro-apoptotic protein, which initiates intrinsic apoptotic pathway and causes apoptosis. BIM initiates apoptosis upon upregulation by tyrosine kinase inhibitors (TKI) and binds to pro-survival Bcl2 family through its SH3 domain. BIM is a key factor to evaluate cancer therapy outcomes. Downregulation of BCL2L11 by either polymorphism or promoter hypermethylation, results in survival of chronic myeloid leukaemia cells and also provides drug resistance. BCL2L11 is associated with lymphomagenesis. Upregulation of MicroRNA (miR-24) suppresses BCL2L11 expression in gastrointestinal tumour, promotes cell proliferation and invasion.
Features and Benefits
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Target description
Induces apoptosis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than the isoforms BimEL, BimL and BimS. Isoform Bim-gamma induces apoptosis.
Physical form
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Shipping Information:
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- UPC:
- 51111775
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- SAB4300531-100UG
- Temperature Control Device:
- Yes
