ANTI-CALCIUM CHANNEL (ALPHA2/DELTA-1 SUBUNIT) (C005B-104117)

General description

CACNA2D1 (calcium channel, voltage-dependent, α2/δ subunit 1) is a member of a family of GPI-anchored voltage-gated calcium channels (VGCCs)-associated subunits called α2δ. VGCC are composed of three types of subunits- pore-forming α1 and auxiliary β and α2δ subunits.

Immunogen

synthetic peptide corresponding to amino acids 1-15 of α₂ subunit (amino acids 27-41 of rabbit α₂/δ−1 precursor).

Application

Anti-Calcium Channel (α2/δ-1 Subunit) antibody produced in rabbit has been used in immunoblotting and immunofluorescence.

Biochem/physiol Actions

CACNA2D1 (calcium channel, voltage-dependent, α2/δsubunit 1) is a type of α2δs, which are involved in the synaptic neurotransmitter release as they are concentrated at the synapses. They have a chaperone-like activity in non-neuronal cells. This protein acts as a target for gabapentin, which is a neuropathic analgesic. Mutations in this gene, in humans result in short QT syndrome (SQTS).

Target description

L-type of Voltage-gated Ca²⁺ Channel.

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, and 0.05% sodium azide.

Preparation Note

Reconstitute the 0.05 mL vial with 50 μL deionized water. Reconstitute the 0.2 mL vial with 0.2 mL deionized water. After reconstitution, the antibody concentration is ~0.8 mg/mL.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.