Skip to main content

ANTI-CALML5 CLONE 3F6.1

Catalog No.
C005B-449779
Mfr. No.
MABN1583
Mfr. Name
Sigma-Aldrich
Qty/UOM
1
UOM
EA
Price: $778.62
List Price: $865.14

General description Calmodulin-like protein 5 (UniProt Q9NZT1: also known as Calmodulin-like skin protein) is encoded by the CALML5 (also known as CLSP) gene (Gene ID 51806) in human. Epidermal differentiation and barrier function depend on many

Enjoy exclusive benefits including discounted pricing on orders by contacting our Sales Executives to open an account. Contact Us

Adding to cart… The item has been added

General description

Calmodulin-like protein 5 (UniProt Q9NZT1; also known as Calmodulin-like skin protein) is encoded by the CALML5 (also known as CLSP) gene (Gene ID 51806) in human. Epidermal differentiation and barrier function depend on many calcium-regulated proteins and enzymes. CALML5/CLSP is expressed in the stratum granulosum and lower layers of the stratum corneum of the skin, where it modulates the function of calcium-dependent proteins, such as transglutaminase 3. CALML5/CLSP level is upregulated in granular and spinal keratinocytes during the later stages of wound healing in human epidermis and eventually returns to basal level once the wound is closed and barrier function has been restored. In the hyperproliferative skin disorders psoriasis and atopic dermatitis (AD), the permeability barrier is disturbed, causing an increased CLSP built-up as a result of decresed CLSP degradation due to an altered calcium gradient.

Specificity

Clone 3F6.1 recognizes an epitope outside the first EF-hand motif.

Immunogen

Epitope: Outside the first EF-hand motif.

GST-tagged recombinant human CALML5 lacking the first EF-hand motif.

Application

Anti-CALML5 Antibody, clone 3F6.1 is an antibody against CALM5 for use in Western Blotting, Immunohistochemistry (Paraffin).

Immunohistochemistry Analysis: A 1:50-1,000 dilution from a representative lot detected CALML5 in human tonsil and skin tissue sections.

Research Category
Neuroscience

Research Sub Category
Developmental Neuroscience

Quality

Evaluated by Western Blotting of human CALML5 GST fusion protein.

Western Blotting Analysis: 0.05 µg/mL of this antibody detected 0.05 µg of human CALML5 GST fusion protein.

Target description

15.89 kDa calculated. Uncharacterized band(s) may appear in some lysates.

Physical form

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Other Notes

Concentration: Please refer to lot specific datasheet.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Shipping Information:

Dry Ice Surcharge & Ice Pack Shipments: $40

More Information: https://cenmed.com/shipping-returns

UPC:
51261502
Condition:
New
Availability:
3-5 Days
Weight:
1.00 Ounces
HazmatClass:
No
MPN:
MABN1583
Temperature Control Device:
Yes

Cenmed Satisfaction Guarantee
Cenmed Satisfaction Guarantee

At Cenmed, your confidence and satisfaction are paramount. We guarantee the quality and reliability of our extensive range of clinical and laboratory supplies. If you're not completely satisfied with your purchase, we offer a straightforward return process and dedicated support to resolve your concerns promptly. Our commitment ensures that you can order with confidence, knowing that Cenmed is dedicated to superior service and customer satisfaction. Trust us to meet your needs with every order, backed by our promise of excellence. Learn more in Help & FAQs.

Testimonial
"Cenmed provides me access to the same products/services normally reserved for much larger labs than mine. I was presently surprised by their product offering."

LAB DIRECTOR

Testimonial
"We utilized Cenmed's capabilities for a variety of projects around the world. They are a valued partner and supplier."

PHARMACEUTICAL SUPPLY CHAIN LEADER

Testimonial
"The reps are very good at finding products for customers in this period of supply chain issues."

SCOTT BEHMAN

Testimonial
"Your customer service has been excellent and makes me excited about purchasing with Cenmed in the future!!"

PROCUREMENT + BILLING COORDINATOR AT PHARMA.