General description
Caspase-1 is also known as interleukin-1βconverting enzyme (ICE). It is located on chromosome 11q22.2. It has 10 exons, an N terminal CARD (caspase activation and recruitment domain), a large P20 subunit and a small P10 subunit. It is present in leukocytes, monocytes and epithelial cells.
Immunogen
a 15 amino acid peptide from near the middle of human Caspase-1.
Biochem/physiol Actions
Caspase-1 can transform the pro-inflammatory cytokines, interleukin-1β (IL-1β) and IL-18 into their active forms. It participates in pyroptosis. It is overexpressed in the aorta of coronary atherosclerosis patients.It helps in host cell survival by inducing membrane biogenesis to restore the impairment caused by pore-forming toxins.
Linkage
The action of this antibody can be blocked using blocking peptide SBP3463.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide
- UPC:
- 12352203
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- PRS3463-100UG
- Product Size:
- 100/µG
