Anti-Caspr2 antibody produced in rabbit

General description

CASPR2 (Contactin-associated protein-like 2) belongs to CASPR family and neurexin superfamily.

Immunogen

peptide corresponding to amino acids residues 1315-1331 of human Caspr2.

Application

Anti-CASPR2 antibody has been used for immunohistochemitry and western blotting of proteins from mouse brain samples. It is also suitable for western blot analysis at a dilution of 1:200 by using rat brain membranes.

Biochem/physiol Actions

CASPR2 (Contactin-associated protein-like 2) associates shaker like K⁺ channels in the juxtaparanodal region flanking nodes of Ranvier. It is expressed in different and distinct regions of the central nervous system (CNS) where it may plays an important role in cell recognition. CASPR and CASPR2 may interact with the actin-based cytoskeleton through cytoskeleton-associated protein 4.1B. CASPR2 is crucial for synapse formation and outgrowth of axon and dendrite. CASPR2 forms a complex with G-protein-coupled receptor 37 (GPR37) and multiple PDZ domain protein 1 (MUPP1). Disruption of the complex is linked with autism spectrum disorder (ASD). Genetic variations in CASPR2 are also associated with intellectual disability, epilepsy, schizophrenia and language disorders. It also regulates diet-induced obesity.

Physical form

Lyophilized from 0.4 mg/ml in phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, 5% sucrose, and ≤0.1% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.