Anti-CCM2L antibody produced in rabbit (C15-1447-141)

General description

Cerebral cavernous malformation 2-like (CCM2L) is expressed in endothelial cells during cardiovascular growth. It contains a PTB domain comprising of amino acids 45–146 that contains a long insertion between the β6 and β7 sheets.

Immunogen

Uncharacterized protein C20orf160 recombinant protein epitope signature tag (PrEST)

Application

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

Biochem/physiol Actions

Cerebral cavernous malformation 2-like (CCM2L) has been show to block cerebral cavernous malformation 2 (CCM2)-mediated signals in cultured endothelial cells. Loss of its function diminishes the expression of endocardial growth factor and impairs wound healing. CCM2L takes part in a molecular level mechanism by which endothelial cells collectively regulate vessel stability. During cardiovascular development, the vessel growth is initiated and regulated by it. CCM2L may also bind cerebral cavernous malformation 1 (CCM1) and is an important component of the heart of glass-cerebral cavernous malformation (Heg-CCM) pathway.

Features and Benefits

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Linkage

Corresponding Antigen APREST71322.

Physical form

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Legal Information

Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.