Immunogen

Synthetic peptide directed towards the C terminal region of human CDK8

Application

Anti-CDK8 antibody produced in rabbit is suitable for western blotting at a concentration of 1.25 μg/ml.

Biochem/physiol Actions

CDK8 is a regulator of transcription in a multisubunit complex with TFIIH and TEF-β. It exerts positive and negative effects on transcription and is involved signaling that controls nutrient sensing and cell differentiation. CDK8 phosphorylates the regulatory serine residue of STAT1 and mediates JAK-STAT1 signaling.

Sequence

Synthetic peptide located within the following region: GLIMTSDYQRSNPHAAYPNPGPSTSQPQSSMGYSATSQQPPQYSHQTHRY

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.