ANTI-CHI3L2 (C15-1446-347)

General description

Chitinase 3-like 2 (CHI3L2) is very similar to CHI3L1, which in turn belongs to Chitinase-like protein (CLP) family. They have the same residues at their amino acid terminal. CHI3L2 is also called YKL39, and has a molecular weight of 39kDa and is produced and secreted by synoviocytes and articular chondrocytes. It was first obtained from the primary culture of human articular cartilage chondrocytes, where it co-purified with CHI3L1.

Immunogen

Chitinase 3-like protein 2 precursor recombinant protein epitope signature tag (PrEST)

Application

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

Biochem/physiol Actions

Unlike other CLPs (chitinase-like proteins), Chitinase 3-like 2 (CHI3L2), has no hydrolase activity and therefore functions as a pseudo-chitinase. However, it binds to chitooligosaccharides and retains the chitinase-like ligand binding characteristics. Studies suggest that CHI3L2 might act as a growth and differentiation factor in cartilage homeostasis. It might also aid the progression of osteoarthritis as its expression is increased in osteoarthritic articular chondrocytes. It regulates proliferation and differentiation in human embryonic kidney (HEK293) and human glioblastoma (U87 MG) cells via the extracellular signal-regulated kinase (ERK) signaling pathway. High levels of CHI3L2 mRNA have been detected in lung and heart and its expression is up regulated in glioblastomas.

Features and Benefits

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Linkage

Corresponding Antigen APREST70015.

Physical form

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Legal Information

Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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