ANTI-CHL1 (C15-1445-905)

General description

CHL1 (cell adhesion molecule L1-like) is also called as CALL (cell adhesion L1-like) and is expressed in normal tissues, brain, and a variety of human cancer cell lines and primary tumor tissues. The gene is mapped to human chromosome 3p26.3.

Immunogen

Neural cell adhesion molecule L1-like protein precursor recombinant protein epitope signature tag (PrEST)

Application

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

Biochem/physiol Actions

CHL1 (cell adhesion molecule L1-like) gene encodes a one-pass trans-membrane protein belonging to the L1 gene family of neural cell adhesion molecules. The protein is capable of both homotypic and heterotypic binding and may be involved in signal transduction pathways. The gene has been implicated in cancer growth and metastasis and some neurological diseases such as schizophrenia. It also functions in general cognitive activities. Deletion of one copy of this gene causes mental defects in patients with 3p- syndrome. It may serve as a potential biomarker in the early pathogenesis of two major histological types of renal cancer. Deficiency of this protein is found to promote tumor formation and it overexpression suppresses proliferation and invasion. It may be a potential therapeutic target for breast carcinogenesis and progression.

Features and Benefits

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Linkage

Corresponding Antigen APREST86472.

Physical form

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Legal Information

Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.