ANTI-COG1 (C-TERMINAL) ANTIBODY PRODUCED IN RABBIT AFFINITY ISOLATED ANTIBODY

General description

COG1 is a member of the conserved oligomeric Golgi (COG) complex. COG complex is an evolutionarily conserved multi-subunit protein complex. COG complex consists of eight distinct subunits organized in two heterotrimeric groups, Cog2-Cog3-Cog4 and Cog5-Cog6-Cog7, which are linked by the dimeric group formed by Cog1 and Cog8.

Conserved oligomeric Golgi (COG) subunit 1 is an essential component of the conserved oligomeric Golgi complex. It is encoded by the gene mapped to human chromosome 17q25.1.

Immunogen

peptide corresponding to the C-terminal region of human COG1, conjugated to KLH. The corresponding sequence is identical in mouse, rat and monkey COG1.

Application

Anti-COG1 (C-TERMINAL) antibody produced in rabbit has been used in immunoblotting and immunofluorescence.

Biochem/physiol Actions

COG1 is required for steps in the normal medial and trans Golgi-associated processing of glycoconjugates. It plays a role in the organization of the Golgi-localized complex. Mutations in COG1 in humans cause novel types of congenital disorders of glycosylation (CDG). COG complex regulates membrane trafficking and maintenance of Golgi glycosylation machinery in eukaryotic cells.

Conserved oligomeric Golgi (COG) complex plays a vital role in retrograde vesicular trafficking and glycosylation.

Physical form

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

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