ANTI-COPEPTIN ANTIBODY PRODUCED IN RABBIT AFFINITY ISOLATED ANTIBODY

General description

AVP or pre-proAVP, also known as, vasopressin-neurophysin 2-copeptin is one of the main hormones of the axis hypothalamic-pituitary adrenal. It is split into 3 chains: Arg-vasopressin, neurophysin-2 and copeptin. Copeptin is a glycopeptide with 39 amino acids, located at the C-terminal part of the pre-proAVP. It is secreted by the posterior pituitary gland and poured into the systemic circulation.

The gene AVP (arginine vasopressin) is mapped to human chromosome 20. It is an antidiurectic hormone which is produced by hypothalamic neurons.

Immunogen

a synthetic peptide corresponding to the C-terminal region of human Copeptin

Application

Anti-Copeptin antibody produced in rabbit has been used in various immunochemical techniques including :

• immunohistochemistry
• immunoblotting
• immunoprecipitation
• enzyme linked immunosorbent assay (ELISA)

Biochem/physiol Actions

Copeptin concentration directly reflects AVP activation and serves as a biomarker of the AVP system. Altered copeptin levels are implicated in stroke, sudden death and cardiovascular events. It can also be used as a biomarker for a list of illnesses, such as acute myocardial infarction (AMI), vasodilatory shock, metabolic syndrome, diabetes insipidus, diabetes mellitus, sepsis, septic shock, lower respiratory tract infections, hyponatremia, acute dyspnea, autosomal dominant polycystic kidney disease (ADPKD), intracerebral hemorrhage, pulmonary arterial hypertension (PAH) and head injury.

The gene AVP (arginine vasopressin) encodes preprovasopressin which is processed into vasopressin, neurophysin II and glycoprotein (copeptin). Mutations in it are associated with neurohypophyseal diabetes insipidus. It also plays a crucial role in social mannerism, such as recognition, aggression, reproduction and parenting. The levels of circulating copeptin is higher in children suffering from febrile seizures.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

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