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ANTI-CORONIN-1B ANTIBODY PRODUCED IN RABBIT AFFINITY ISOLATED ANTIBODY

Sigma Aldrich

Catalog No.
C15-1739-658
Manufacturer No.
SAB4200096-200UL
Manufacturer Name
Sigma-Aldrich
Quantity
1
Unit of Measure
EA
Price: $1,019.75
List Price: $1,133.06

General description Coronin 1B (CORO1B) is encoded by the gene mapped to human chromosome 11q13.2.

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General description

Coronin 1B (CORO1B) is encoded by the gene mapped to human chromosome 11q13.2. CORO1B belongs to the mammalian coronin gene family. The encoded protein is ubiquitously expressed and is mainly present on the leading edge of migrating fibroblasts.

Coronin-1B localizes to sub-membrane areas.

Application

Anti-Coronin 1B antibody produced in rabbit has been used in immunoblotting and immunofluorescence.

Biochem/physiol Actions

Coronin 1B (CORO1B) acts as an actin binding protein. It also plays a major role in controlling whole-cell motility and lamellipodial dynamics. CORO1B also influence neurite outgrowth in a neuronal regeneration model. The encoded protein antagonizes a filament branch stabilizer, cortactin and disassembles actin-related protein (Arp) 2/3-containing actin filament branches by promoting Arp2/3 dissociation.

Coronin-1B has been shown to affect cell motility by regulation of actin-depolymerizing factor (ADF)/cofilin proteins at the leading edge. It targets the cofilin-activating phosphatase slingshot-1L to the leading edge, and thus indirectly regulates cofilin activity.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

UPC:
12352207
Condition:
New
Availability:
3-5 Days
Weight:
1.00 Ounces
HazmatClass:
No
WeightUOM:
LB
MPN:
SAB4200096-200UL
Product Size:
200/µL

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