General description
Cytokeratins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in epithelial tissues by at least 20 different polypeptides. They range in molecular weight from between 40 kDa and 68 kDa and isoelectric pH between 4.9 - 7.8, The individual cytokeratin polypeptides are designated 1-20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies.
Specificity
Cytokeratin 14. MAB3232 reacts with basal cell compartments of stratified and combined epithelia.Reacts with cytokeratin 14, expressed in the basal cells of the larynx, esophagus, trachea, bladder, prostate, cervix, vagina, breast acini, skin and sweat glands.
Immunogen
Cytoskeletal preparation of TR146 epithelial cells.
Application
Detect Cytokeratin 14 using this Anti-Cytokeratin 14 Antibody, clone RCK107 validated for use in FC, WB, IC, IH.
Research Category
Cell Structure
Research Sub Category
Cytokeratins
Western blot
Immunohistochemistry on frozen tissue sections.
Immunocytochemistry
Flow cytometry
Optimal working dilutions must be determined by the end user.
Physical form
Format: Purified
Liquid in buffer with 0.1% sodium azide.
Storage and Stability
Maintain at -20°C in undiluted aliquots up to 6 months. Avoid repeated freeze/thaw cycles.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Shipping Information:
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- UPC:
- 51111828
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- MAB3232
- Temperature Control Device:
- Yes
