General description
Dock2 (Dedicator of cytokinesis 2), is a large protein involved in intracellular signaling networks and a member of the DOCK-A subfamily which function as activators of small G proteins. Dock2 specifically activates isoforms of the small G protein Rac and appears to be expressed specifically in leukocytes. These cells express both Rac1 and Rac2 and Dock2 has been shown to bind and promote nucleotide exchange on both of these isoforms. (Nishihara, 1999)
Specificity
09-454 recognizes mouse DOCK2.
Predicted to cross react with human, equine, and primate, based on 93% sequence homology (13/14 aa). The sequence is 85.7% homologous in rat. Reactivity with other species has not been tested.
Immunogen
Epitope: Internal region
KLH-conjugated synthetic peptide near amino acid 1730, within the internal region of mouse DOCK2.
Application
Research Category
Cell Structure
Research Sub Category
Cytoskeleton
Western Blotting; Anti-Dock2 Antibody is an antibody against Dock2 for use in WB
Immunohistchemistry (Frozen sections): A representative lot of this antibody dectected DOCK2 in mouse and human brain frozen tissue sections (Cimino, PJ et al. (2009). Am. J. Pathol. 175(4); 1622-1630)
Quality
Evaluated by Western blot on mouse spleen lysate 0.5 μg/mL of Anti-DOCK2 at 1 mg/mL.
Target description
180 kDa
Physical form
Peptide affinity purified
Purified in PBS containing 0.05% NaN3.
Storage and Stability
Maintain at 2-8°C for up to 1 year from date of receipt.
Analysis Note
Control
Mouse spleen lysate
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Shipping Information:
Dry Ice Surcharge & Ice Pack Shipments: $40
More Information: https://cenmed.com/shipping-returns
- UPC:
- 51172200
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- 09-454
- Temperature Control Device:
- Yes
