General description
Problems in the CNS dopaminergic system are thought to be the root cause of some neuropsychiatric disorders. Dopamine D2 receptor is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Dopamine D2 receptor signaling using Nurr1 and ERK may play an important role in mesencephalic dopaminergic neuronal development. Faulty D2 receptors have been common in cases of ROS-dependent hypertension. In addition, defects in DRD2 are associted with alcohol-responsive dystonia, varying susceptability to familial alcoholism as well as a contributing factor to the suicide risk in alcoholics.
Immunogen
Linear peptide corresponding to human Dopamine D2 receptor.
Application
Immunocytochemistry Analysis: A previous lot was used by an independent laboratory to detect Dopamine D2 receptor in Ntera-2 cells and in rat brain neurons. Courtesy of Glenn Morris, Wolfson Centre for Inherited Neuromuscular Disease.
This Anti-Dopamine D2 receptor (DRD2) Antibody, clone 2B9 is validated for use in WB, IC for the detection of Dopamine D2 receptor (DRD2).
Quality
Evaluated by Western Blot in rat spinal cord tissue lysate.
Western Blot Analysis: 5 µg/mL of this antibody detected Dopamine D2 receptor on 10 µg of rat spinal cord tissue lysate.
Target description
~50 kDa observed
Physical form
Format: Purified
Analysis Note
Control
Rat spinal cord tissue lysate
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
- UPC:
- 51332101
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- MABN53
- Product Size:
- 200/µG
