ANTI-ENDOTHELIN B RECEPTOR ANTIBODY DEVELOPED IN RABBIT AFFINITY ISOLATED ANTIBODY

Immunogen

synthetic peptide corresponding to the N-terminal extracellular domain of human endothelin B receptor, conjugated to KLH. The immunizing peptide has 79% homology with the mouse gene and 84% homology with the rat gene.

Application

Anti-Endothelin B Receptor antibody produced in rabbit is suitable for the following applications:

• Immunocytochemistry at a concentration of 4-11μg/mL using human adrenal tissue
• Immunohistochemistry (formalin-fixed, paraffin-embedded sections) at a concentration of 4-11μg/mL using human adrenal tissue
• Western blotting
• Immunofluorescence

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)

Biochem/physiol Actions

EDNRB Endothelin receptor type B (ETB) is a protein encoded by the EDNRB gene in humans. It plays a pivotal role in oesophageal cancer and may act as a therapeutic target for this intractable malignancy. It has a novel role in oligodendroglioma proliferation and acts as a potential therapeutic alternative for oligodendrogliomas. Lower expression of ETB receptor responsiveness is associated with polycystic ovary syndrome (PCOS) and may reflect lower endothelial-mediated vasodilatation independent of generally lower vascular reactivity.

Physical form

Solution in phosphate buffered saline, pH 7.7, containing 0.1% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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