ANTI-ERLEC1 (C005B-208761)

General description

Endoplasmic reticulum lectin 1 (ERLEC1), also called Erlectin (XTP3-B), belongs to mannose 6-phosphate receptor homology (MRH) domain family. It has a signal peptide and two MRH domains. The ERLEC1 gene is mapped to human chromosome 2p16.2.

Immunogen

endoplasmic reticulum lectin 1 recombinant protein epitope signature tag (PrEST)

Application

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

Biochem/physiol Actions

Endoplasmic reticulum lectin 1 (ERLEC1) plays a key role in sorting of misfolded glycoproteins and their endoplasmic reticulum-associated degradation (ERAD). In mammals, ERLEC1 coordinates with amplified in osteosarcoma 9 (OS-9) and monitors protein misfolding and channelizes them for ubiquitin conjugation and degradation. It interacts with endoplasmic reticulum chaperones GRP94 (94-kDa glucose-regulated protein, an ER Hsp90 family member) and BiP (immunoglobulin heavy chain-binding protein, an ER Hsp70 family member) through the MRH domain.

Features and Benefits

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Linkage

Corresponding Antigen APREST78933.

Physical form

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

Legal Information

Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC

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