General description
Fructose-1, 6-bisphosphatase 1 (FBPase 1), also known as D-fructose-1, 6-bisphosphate 1-phosphohydrolase 1, and encoded by the gene name FBP1 and FBP, belongs to the FBPase class 1 family. FBPase 1 is a gluconeogenesis regulatory enzyme that catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations; thus, acting as a rate-limiting enzyme in gluconeogenesis. FBPase 1 has been demonstrated to play a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. FBPase 1 may be involved in modulating glycerol gluconeogenesis in liver. FBPase 1 has been studied as an important regulator of appetite and adiposity. Increased expression of FBPase 1 in liver, after nutrient excess, increases circulating satiety hormones and reduces appetite-stimulating neuropeptides. Therefore, FBPase 1 may be an important target that provides a feedback mechanism to limit weight gain. FBPase 1 is expressed mainly in pancreatic islets.
Immunogen
KLH-conjugated linear peptide corresponding to human FBPase 1.
Application
Anti-FBPase 1, clone 13A8.1 | MABC543 is an antibody against FBPase 1 for use in Western Blotting, Immunohistochemistry (Paraffin).
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected FBPase 1 in human pancreas tissue.
Quality
Evaluated by Western Blotting in mouse stomach tissue lysate.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected FBPase 1 in 10 µg of mouse stomach tissue lysate.
Target description
~36 kDa observed. Uncharacterized band(s) may appear in some lysates.
Physical form
Format: Purified
Other Notes
Concentration: Please refer to lot specific datasheet.
- UPC:
- 51202301
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- MABC543
- Product Size:
- 100/µL
