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ANTI-FEN-1 ANTIBODY PRODUCED IN RABBIT

Sigma Aldrich

Catalog No.
C15-1730-175
Manufacturer No.
SAB5701665-100UL
Manufacturer Name
Sigma-Aldrich
Quantity
1
Unit of Measure
EA
Price: $758.66
List Price: $842.95

General description The protein encoded by this gene removes 5&apos: overhanging flaps in DNA repair and processes the 5&apos: ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP

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General description

The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq, Jul 2008]

Immunogen

A synthesized peptide derived from human FEN-1

Physical form

Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

UPC:
51201516
Condition:
New
Availability:
3-5 Days
Weight:
1.00 Ounces
HazmatClass:
No
WeightUOM:
LB
MPN:
SAB5701665-100UL
Product Size:
1/EA

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